The cees dekker Diaries
The cees dekker Diaries
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Nanotechnology presents An array of opportunities to contribute to biology. Listed here I will current examples the place nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
Our team scientific tests bacterial cell division and it is aiming to constitute a ‘base up biology’ in artificial cells that could autonomously divide. Our major curiosity lies in cell division, chromatin framework, and spatial Management.
, Groningen researchers current the effects in their endeavours to make labs much more sustainable and provide techniques for other labs.
Due to the fact 2000, Dekker has shifted the main concentration of his work in direction of biophysics wherever he research the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, as well as from the extended-expression point of view that many intriguing discoveries might be envisioned in this field.[5] Present lines of analysis in his biophysics group are inside the regions of:[6]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time research of your dynamics DNA supercoils and the discovery of supercoil hopping
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
‘At the beginning we looked at biological programs which has a physical look at and acted on The premise from the instruments we realized. It took a few years just before we started off working a lot more on the large Organic challenges. I then began to contact it nanobiology, a phrase that did not exist at enough time.
Learning DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
The rotors harness Electricity from a nanoscale h2o and ion circulation which is created by a static chemical or electrochemical probable gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological situations, suggesting ways to setting up Power-transducing motors at nanoscale interfaces.
But carbon nanotubes have remained a research topic of sizeable desire to quite a few. In fact, the outlook on working with carbon nanotubes to create functional units, in locations like radio-frequency electronics, electronic electronics and versatile electronics, stays vibrant.
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Cees Dekker is Distinguished College Professor at TU Delft. Qualified being a physicist, he pioneered nanotechnology with a lot of discoveries on carbon nanotubes while in the nineties. Given that 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is an elected member of ceesdekker.net the KNAW and fellow into the APS plus the IOP.
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It was an incredibly attention-grabbing time, throughout which I acquired loads of assistance from Delft University of Know-how, where I was a professor at time, and I started off quite a few collaborations with molecular biologists. That helped me find out a good deal.’